Synthesis and biological activity of enantiomeric pairs of phosphosulfonate herbicides.
J Agric Food Chem
; 47(1): 318-21, 1999 Jan.
Article
en En
| MEDLINE
| ID: mdl-10563892
ABSTRACT
The phosphosulfonates are a new class of soil-active herbicides which control a variety of annual grass and broadleaf weeds. Chirality at the phosphorus atom afforded the opportunity to explore stereospecific requirements for herbicidal activity. Chiral (hydroxymethyl)phosphinate intermediates were enzymatically resolved (Pseudomonas fluorescens lipase) from the racemic mixtures and then used to prepare two pairs of enantiomeric phosphosulfonates. Biological testing of the enantiomeric phosphosulfonate herbicides demonstrated that, in each case, the herbicidal activity was attributed to the (+) enantiomer and that the (+) enantiomer is more active than the racemate.
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Base de datos:
MEDLINE
Asunto principal:
Ácidos Sulfónicos
/
Herbicidas
Idioma:
En
Revista:
J Agric Food Chem
Año:
1999
Tipo del documento:
Article