In-vitro and in-vivo activities of SCH56592 against Cryptococcus neoformans.
J Antimicrob Chemother
; 44(6): 827-9, 1999 Dec.
Article
en En
| MEDLINE
| ID: mdl-10590286
ABSTRACT
The in-vitro and in-vivo activities of SCH56592, a triazole antifungal agent, against Cryptococcus neoformans were studied. MIC(90)s for 16 strains of C. neoformans measured by microdilution method (NCCLS M27-A) were 1 mg/L of SCH56592, 16 mg/L of fluconazole, 32 mg/L of flucytosine, and 0.5 mg/L of amphotericin B. In a murine model of pulmonary cryptococcosis, 10 mg/kg of SCH56592 was more effective than fluconazole. The fungal burden of the lung of animals treated with SCH56592 was significantly reduced (7.40 +/- 0.21 log(10) cfu/g), as compared with fluconazole (7.77 +/- 0.07 log(10) cfu/g) and control (7.79 +/- 0.1 log(10) cfu/g) (P < 0.01). For C. neoformans-infected mice following 7 days treatment with 10 mg/kg of SCH56592 there was a higher concentration in lung (3.36 +/- 0.62 ng/ml) than in plasma (2.16 +/- 0.86 ng/mL), and this was maintained for 12 h after administration.
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Base de datos:
MEDLINE
Asunto principal:
Triazoles
/
Criptococosis
/
Cryptococcus neoformans
/
Antifúngicos
Idioma:
En
Revista:
J Antimicrob Chemother
Año:
1999
Tipo del documento:
Article