Characterization of tick-borne encephalitis virus from Latvia.
J Med Virol
; 60(2): 216-22, 2000 Feb.
Article
en En
| MEDLINE
| ID: mdl-10596024
ABSTRACT
Viruses of the tick-borne encephalitis (TBE) antigenic complex, within the family Flaviviridae, cause a variety of diseases including uncomplicated febrile illness, encephalitis, meningo-encephalitis, hemorrhagic fever and chronic disease in humans, domesticated animals or wildlife species. TBE is a serious problem in Latvia with up to a 1,000 patients confirmed serologically annually 1994-1995. No previous data had been reported on the causative agent of TBE in Latvia. In the present study, a virus was isolated from serum of a patient with clinical symptoms of an acute TBE infection. Nucleotide sequence information obtained by direct reverse transcription-polymerase chain reaction (RT-PCR) and the serological characteristics of the isolated virus strain, designated TBE-Latvia-1-96, indicated a closer relationship to the Vasilchenko strain, isolated in Novosibirsk (Siberia, Russia), as compared to the western European or far eastern subtypes of TBE viruses. In a mouse neurovirulence assay, a significant difference in survival rates (days) was shown between Latvia-1-96 and the western European TBE virus subtype.
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Base de datos:
MEDLINE
Asunto principal:
Proteínas del Envoltorio Viral
/
Encefalitis Transmitida por Garrapatas
/
Virus de la Encefalitis Transmitidos por Garrapatas
Tipo de estudio:
Diagnostic_studies
País/Región como asunto:
Europa
Idioma:
En
Revista:
J Med Virol
Año:
2000
Tipo del documento:
Article