Enantioselective Total Synthesis of Epothilone A Using Multifunctional Asymmetric Catalyses.
Angew Chem Int Ed Engl
; 39(1): 209-213, 2000 Jan.
Article
en En
| MEDLINE
| ID: mdl-10649378
ABSTRACT
A catalytic version has now been developed for the enantioselective total synthesis of epothilone A (1). The key is the use of multifunctional asymmetric catalyses for a direct aldol reaction and cyanosilylation. This successful approach demonstrated the usefulness of these reactions for the catalytic asymmetric synthesis of complex molecules.
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Base de datos:
MEDLINE
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Año:
2000
Tipo del documento:
Article