The c-myc locus is a common integration site in type B retrovirus-induced T-cell lymphomas.
J Virol
; 74(5): 2466-71, 2000 Mar.
Article
en En
| MEDLINE
| ID: mdl-10666282
ABSTRACT
Type B leukemogenic virus (TBLV) induces rapidly appearing T-cell leukemias. TBLV insertions near the c-myc gene were detectable in 2 of 30 tumors tested, whereas 80% of the tumors showed c-myc overexpression. TBLV insertions on chromosome 15 (including a newly identified locus, Pad7) may cause c-myc overexpression by cis-acting effects at a distance.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Genes myc
/
Linfoma de Células T
/
Betaretrovirus
Idioma:
En
Revista:
J Virol
Año:
2000
Tipo del documento:
Article