A commercial preparation of catalase inhibits nitric oxide production by activated murine macrophages: role of arginase.
Infect Immun
; 68(5): 3015-8, 2000 May.
Article
en En
| MEDLINE
| ID: mdl-10769006
Catalase is widely used as a pharmacological probe to evaluate the role of hydrogen peroxide in antimicrobial activities of phagocytic cells. This report demonstrates that the ability of a commercial preparation of catalase to inhibit concomitantly macrophage antimycobacterial activity and production of reactive nitrogen intermediates can be attributed, at least in part, to the depletion of L-arginine by contaminating arginase. In experimental systems that employ pharmacological probes, the existence of nonspecific effects should be considered in data interpretation.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Arginasa
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Catalasa
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Macrófagos Peritoneales
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Óxido Nítrico
Idioma:
En
Revista:
Infect Immun
Año:
2000
Tipo del documento:
Article