Hydration changes implicated in the remarkable temperature-dependent membrane permeation of cyclosporin A.

Augustijns, P F; Brown, S C; Willard, D H; Consler, T G; Annaert, P P; Hendren, R W; Bradshaw, T P

Augustijns, P F; Brown, S C; Willard, D H; Consler, T G; Annaert, P P; Hendren, R W; Bradshaw, T P.

Afiliación

Augustijns PF; Biophysical and Structural Chemistry Department, Molecular Sciences Department and Biopharmaceutical Development, Glaxo Wellcome Inc., RTP, North Carolina 27709, USA.

Biochemistry ; 39(25): 7621-30, 2000 Jun 27.

Article en En | MEDLINE | ID: mdl-10858313

Asunto(s)

Ciclosporina/metabolismo; Células CACO-2; Membrana Celular/metabolismo; Permeabilidad de la Membrana Celular; Humanos; Espectroscopía de Resonancia Magnética; Solubilidad; Temperatura; Agua/química

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