Neurological disease-associated autoantibodies against an unknown protein encoded by a RES4-22 homologous gene.
Scand J Immunol
; 53(2): 204-8, 2001 Feb.
Article
en En
| MEDLINE
| ID: mdl-11169226
ABSTRACT
Screening a human small intestinal library with human serum yielded a clone which encoded a protein res4-22 the gene of which was highly homologous to a recently described gene located in the Huntington's disease locus. Autoantibodies against res4-22 (anti-res4-22), mainly of the immunoglobulin (Ig)A type, were detected in patients with neurological disorders at a higher frequency (18.4%) than in healthy blood donors (8.0%). In neurological patients with cerebral ischaemia anti-res4-22 was found significantly more often (47.4%) than in the total group of neurological patients. Anti-res4-22 positive sera showed significantly more frequently myelin staining in cerebellum and nerve sections than anti-res4-22 negative sera. Our findings demonstrate a new species of human autoantibodies against a newly described protein the function of which is still unknown.
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Base de datos:
MEDLINE
Asunto principal:
Autoanticuerpos
/
Autoantígenos
/
Cromosomas Humanos Par 4
/
Inmunoglobulina A
/
Proteínas del Tejido Nervioso
/
Enfermedades del Sistema Nervioso
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
Scand J Immunol
Año:
2001
Tipo del documento:
Article