Chemoprotective activity of boldine: modulation of drug-metabolizing enzymes.
Pharmazie
; 56(3): 242-3, 2001 Mar.
Article
en En
| MEDLINE
| ID: mdl-11265593
ABSTRACT
Possible chemoprotective effects of the naturally occurring alkaloid boldine, a major alkaloid of boldo (Peumus boldus Mol.) leaves and bark, including in vitro modulations of drug-metabolizing enzymes in mouse hepatoma Hepa-1 cell line and mouse hepatic microsomes, were investigated. Boldine manifested inhibition activity on hepatic microsomal CYP1A-dependent 7-ethoxyresorufin O-deethylase and CYP3A-dependent testosterone 6 beta-hydroxylase activities and stimulated glutathione S-transferase activity in Hepa-1 cells. In addition to the known antioxidant activity, boldine could decrease the metabolic activation of other xenobiotics including chemical mutagens.
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Base de datos:
MEDLINE
Asunto principal:
Aporfinas
/
Plantas Medicinales
/
Preparaciones Farmacéuticas
/
Oxigenasas de Función Mixta
/
Antioxidantes
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Pharmazie
Asunto de la revista:
FARMACIA
Año:
2001
Tipo del documento:
Article