Analysis of IL-12 receptor beta 2 chain expression of circulating T lymphocytes in patients with atopic asthma.
Cell Immunol
; 208(1): 34-42, 2001 Feb 25.
Article
en En
| MEDLINE
| ID: mdl-11277617
ABSTRACT
Th2 cell predominance relative to Th1 cells contributes to pathological immune responses in patients with atopic asthma. IL-12 is a key cytokine in the induction of Th1 cells, and downregulation of IL-12 production is reported in these patients. However, IL-12 receptor expression of their T lymphocytes has not been clarified. In this study, expression of IL-12 receptor beta 2 on T cells and secretion of cytokines which affect IL-12 receptor beta 2 expression by their PBMC were examined. We found that IL-12 receptor beta 2 expression of the T cells is reduced. This is partly due to the diminished production of IL-12 and enhanced secretion of IL-4 by their PBMC. IL-18 production is not significantly modulated in these patients. Furthermore, intrinsic defects of the CD4(+) T cells, which reduce their IL-12 receptor beta 2 expression in response to IL-12 and/or IL-18 stimulation, are evident and are importantly involved in the Th1/Th2 imbalance of patients with atopic asthma.
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Base de datos:
MEDLINE
Asunto principal:
Asma
/
Linfocitos T
/
Receptores de Interleucina
Idioma:
En
Revista:
Cell Immunol
Año:
2001
Tipo del documento:
Article