Extremely small sample size in some toxicity studies: an example from the rabbit eye irritation test.
Regul Toxicol Pharmacol
; 33(2): 187-91, 2001 Apr.
Article
en En
| MEDLINE
| ID: mdl-11350201
ABSTRACT
The conventional sample-size equations based on either the precision of estimation or the power of testing a hypothesis may not be appropriate to determine sample size for a "diagnostic" testing problem, such as the eye irritant Draize test. When the animals' responses to chemical compounds are relatively uniform and extreme and the objective is to classify a compound as either irritant or nonirritant, the test using just two or three animals may be adequate.
Buscar en Google
Base de datos:
MEDLINE
Asunto principal:
Pruebas de Toxicidad
/
Ojo
/
Oftalmopatías
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Regul Toxicol Pharmacol
Año:
2001
Tipo del documento:
Article