The prognostic significance of day 3 embryo cleavage stage on subsequent blastocyst development in a sequential culture system.
J Assist Reprod Genet
; 18(10): 548-50, 2001 Oct.
Article
en En
| MEDLINE
| ID: mdl-11702768
ABSTRACT
PURPOSE:
To determine prognostic significance of blastomere number on Day 3 of culture upon subsequent blastocyst (BL) development.METHODS:
A retrospective analysis was conducted in 37 IVF subjects undergoing standard protocols and BL transfer after sequential embryo culture in P1 and BL media.RESULTS:
Of Day 3 embryos containing 7 or more blastomeres, 68.9% (186/270) developed into BL compared to embryos containing 4-6 blastomeres, 38.1% (56/147), P < 0.0001. The majority of BL, 68.9% (168/244), were observed on Day 5. Extended Day 6 culture represented 31.1% (76/244) of all BLs.CONCLUSIONS:
The observation of 7 or more blastomeres on Day 3 yielded a significantly greater likelihood of BL development. Embryos containing 4-6 blastomeres are still relatively likely to progress to a BL. Extended culture to Day 6 still yields a significant proportion of BL. Cell cleavage stage on Day 3 appears to be a useful prognostic indicator of subsequent BL development.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Blastocisto
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Blastómeros
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Fertilización In Vitro
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Transferencia de Embrión
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Desarrollo Embrionario y Fetal
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Idioma:
En
Revista:
J Assist Reprod Genet
Asunto de la revista:
GENETICA
/
MEDICINA REPRODUTIVA
Año:
2001
Tipo del documento:
Article