Inducible, but not constitutive, resistance of gonococci to hydrophobic agents due to the MtrC-MtrD-MtrE efflux pump requires TonB-ExbB-ExbD proteins.
Antimicrob Agents Chemother
; 46(2): 561-5, 2002 Feb.
Article
en En
| MEDLINE
| ID: mdl-11796379
ABSTRACT
The MtrC-MtrD-MtrE efflux pump possessed by Neisseria gonorrhoeae is very similar to the MexA-MexB-OprM efflux pump of Pseudomonas aeruginosa. Because the antimicrobial resistance property afforded by the MexA-MexB-OprM efflux pump also requires the TonB protein, we asked whether a similar requirement exists for the gonococcal efflux pump. Unlike earlier studies with P. aeruginosa, we found that constitutive levels of gonococcal resistance to hydrophobic antimicrobial agents (i.e., Triton X-100 [TX-100]) did not require the TonB, ExbB, or ExbD protein. However, inducible levels of TX-100 resistance in gonococci had an absolute requirement for the TonB-ExbB-ExbD system, suggesting that such resistance in gonococci has an energy requirement above and beyond that required for constitutive pump activity.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Proteínas de Transporte de Membrana
/
Tensoactivos
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Octoxinol
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Farmacorresistencia Bacteriana
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Neisseria gonorrhoeae
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2002
Tipo del documento:
Article