Antioxidant enzyme level in the testes of cirrhotic rats.
Nutrition
; 18(1): 56-9, 2002 Jan.
Article
en En
| MEDLINE
| ID: mdl-11827766
ABSTRACT
OBJECTIVES:
An understanding of the tissue and organ level of antioxidant enzymes that scavenge reactive oxygen species may provide an indication of their susceptibility to free radical-related cytotoxic damage. A direct association between testicular production of excessive reactive oxygen species and male infertility has been noted. We measured the activities of superoxide dismutase and glutathione peroxidase in the testes of thioacetamide-induced cirrhotic rats.METHODS:
Antioxidant enzyme activities and trace element levels (copper, zinc, manganese, and selenium) in the testes of thioacetamide-induced cirrhotic and control rats were measured. The statistical difference between the experimental and control groups with regard to the activities of superoxide dismutase and glutathione peroxidase and levels of trace elements was analyzed with Student's t test.RESULTS:
Our results showed a significant decrease in the activity of these enzymes in the testes of cirrhotic rats. The testicular levels of copper, zinc, and manganese, which are associated with these antioxidant enzymes, increased, whereas selenium decreased slightly in cirrhotic rats; that decrease was not statistically significant.CONCLUSIONS:
Our studies showed a drastic decrease in the level of antioxidant enzymes in the testes of cirrhotic rats that could have deleterious effects on sperm function in these animals. Further studies are necessary to understand the exact pathways of trace element metabolism in the testes of cirrhotic rats.
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Base de datos:
MEDLINE
Asunto principal:
Superóxido Dismutasa
/
Testículo
/
Depuradores de Radicales Libres
/
Glutatión Peroxidasa
/
Infertilidad Masculina
/
Cirrosis Hepática Experimental
Tipo de estudio:
Etiology_studies
Idioma:
En
Revista:
Nutrition
Asunto de la revista:
CIENCIAS DA NUTRICAO
Año:
2002
Tipo del documento:
Article