Levels of total tau and tau protein phosphorylated at threonine 181 in patients with incipient and manifest Alzheimer's disease.
Neurosci Lett
; 339(2): 172-4, 2003 Mar 20.
Article
en En
| MEDLINE
| ID: mdl-12614922
ABSTRACT
Cerebrospinal fluid tau protein levels are considered to be a promising marker for Alzheimer's disease (AD) and may facilitate early detection. Using the newly developed INNOTEST Phospho-Tau((181P)) kit examination of total tau and tau protein phosphorylated at threonine 181 (phospho-tau 181) revealed significantly (P<0.05) higher values in both patients with incipient and manifest AD than in controls. In patients with vascular dementia, phospho-tau 181 levels were not different from controls but were significantly lower than in patients with manifest AD. These findings suggest that total and phosphorylated tau protein may facilitate early detection and differential diagnosis of AD.
Buscar en Google
Base de datos:
MEDLINE
Asunto principal:
Treonina
/
Proteínas tau
/
Enfermedad de Alzheimer
Tipo de estudio:
Diagnostic_studies
/
Screening_studies
Idioma:
En
Revista:
Neurosci Lett
Año:
2003
Tipo del documento:
Article