Side-chain-to-tail thiolactone peptide inhibitors of the staphylococcal quorum-sensing system.
Bioorg Med Chem Lett
; 13(15): 2449-53, 2003 Aug 04.
Article
en En
| MEDLINE
| ID: mdl-12852941
ABSTRACT
The expression of many staphylococcal virulence factors are regulated by the agr locus via a two-component signal transduction system (TCSTS), which is activated in response to a secreted autoinducer peptide (AIP). By exploiting the unique chemical architecture of the naturally occurring AIP-1, several potent inhibitors of staphylococcal TCSTS were designed and synthesized using either a linear or branched solid-phase approach. These inhibitors are competitive binders and contain the crucial 16-membered side-chain-to-tail thiolactone peptide pharmacophore.
Buscar en Google
Base de datos:
MEDLINE
Asunto principal:
Péptidos
/
Staphylococcus
/
4-Butirolactona
/
Lactonas
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2003
Tipo del documento:
Article