Humoral and cellular autoimmune responses in stiff person syndrome.
Ann N Y Acad Sci
; 998: 215-22, 2003 Sep.
Article
en En
| MEDLINE
| ID: mdl-14592879
ABSTRACT
Stiff person syndrome (SPS) is a chronic autoimmune disease associated with humoral and cellular immune responses to glutamic acid decarboxylase (GAD) 65. Another chronic autoimmune disease, type 1 diabetes (T1D), is also associated with autoimmune responses to this antigen, but T1D patients develop SPS only extremely rarely and only a third of SPS patients develop T1D (mostly mild manifestations in adulthood). In a previous study, we described important differences between T1D and SPS in the autoimmune response to GAD 65 (1) T cells of SPS patients recognize epitopes in the middle of GAD 65 (amino residues 81-171 and 313-403), whereas patients with T1D preferentially recognize another middle (161-243) and a C-terminal region (473-555); and (2) GAD antibodies (Abs) were nearly exclusively of the Th1-associated IgG1 type in T1D, whereas SPS patients had both Th1- and Th2-associated IgG4 and IgE GAD Abs. These differences were not simply related to different HLA alleles. Fine epitope mapping revealed further distinct T cell epitopes in both diseases despite similar HLA background. Therefore, a single autoantigen can elicit different immune responses causing distinct chronic autoimmune diseases possibly related to a Th1 or Th2 bias of the disease.
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Base de datos:
MEDLINE
Asunto principal:
Autoinmunidad
/
Síndrome de la Persona Rígida
/
Glutamato Descarboxilasa
/
Inmunidad Celular
/
Isoenzimas
/
Formación de Anticuerpos
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Ann N Y Acad Sci
Año:
2003
Tipo del documento:
Article