Mechanisms of TfR-mediated transcytosis and sorting in epithelial cells and applications toward drug delivery.
Adv Drug Deliv Rev
; 55(11): 1439-66, 2003 Nov 14.
Article
en En
| MEDLINE
| ID: mdl-14597140
ABSTRACT
Transferrin receptor has been an important protein for many of the advances made in understanding the intricacies of the intramolecular sorting pathways of endocytosed molecules. The unique internalization and recycling functions of transferrin receptor have also made it an attractive choice for drug targeting and delivery of large protein-based therapeutics and toxins. Recent advances in elucidating the role of the intracellular controllers of transferrin recycling and sorting, such as Rab proteins and their effectors, have led to enhancement of transferrin receptor as a drug delivery vehicle. This review focuses on the use of transferrin receptor as an agent for facilitating drug delivery and targeting, and the role that mechanisms of transferrin receptor sorting and transcytosis play in these events.
Buscar en Google
Base de datos:
MEDLINE
Asunto principal:
Receptores de Transferrina
/
Sistemas de Liberación de Medicamentos
/
Endocitosis
/
Células Epiteliales
Idioma:
En
Revista:
Adv Drug Deliv Rev
Asunto de la revista:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Año:
2003
Tipo del documento:
Article