Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 3: 5-Substituted 3-phenyl-1,2,4-oxadiazoles as potent antagonists.

Gfesser, Gregory A; Zhang, Henry; Dinges, Jurgen; Fox, Gerard B; Pan, Jia Bao; Esbenshade, Timothy A; Yao, Betty B; Witte, David; Miller, Thomas R; Kang, Chae-Hee; Krueger, Kathy M; Bennani, Youssef L; Hancock, Arthur A; Faghih, Ramin

Gfesser, Gregory A; Zhang, Henry; Dinges, Jurgen; Fox, Gerard B; Pan, Jia Bao; Esbenshade, Timothy A; Yao, Betty B; Witte, David; Miller, Thomas R; Kang, Chae-Hee; Krueger, Kathy M; Bennani, Youssef L; Hancock, Arthur A; Faghih, Ramin.

Afiliación

Gfesser GA; Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA. greg.gfesser@abbott.com

Bioorg Med Chem Lett ; 14(3): 673-6, 2004 Feb 09.

Article en En | MEDLINE | ID: mdl-14741266

ABSTRACT

ABSTRACT

Further SAR studies on novel histamine H(3) receptor antagonists are presented. Compound 14bb is a potent antagonist of both the rat cortical and human clone receptors, and is demonstrated to act functionally as an antagonist in an in vivo mouse dipsogenia model.

Asunto(s)

Antagonistas de los Receptores Histamínicos/química; Antagonistas de los Receptores Histamínicos/farmacología; Oxadiazoles/química; Oxadiazoles/farmacología; Receptores Histamínicos H3/química; Receptores Histamínicos H3/efectos de los fármacos; Animales; Humanos; Ligandos; Ratones; Modelos Animales; Estructura Molecular; Ratas; Receptores Histamínicos H3/metabolismo; Relación Estructura-Actividad

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Base de datos: MEDLINE Asunto principal: Oxadiazoles / Receptores Histamínicos H3 / Antagonistas de los Receptores Histamínicos Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2004 Tipo del documento: Article

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