Striatal dopamine transporter in dementia with Lewy bodies and Parkinson disease: a comparison.
Neurology
; 62(9): 1568-72, 2004 May 11.
Article
en En
| MEDLINE
| ID: mdl-15136683
ABSTRACT
OBJECTIVE:
To study the nigrostriatal pathways in 21 patients with dementia with Lewy bodies (DLB), 19 drug naive Parkinson disease (PD) patients, and 16 controls using a dopaminergic presynaptic ligand [123I]-2beta-carbometoxy-3beta-(4-iodophenyl)-N-(3-fluoropropyl) nortropane (FP-CIT) and SPECT in order to assess similarities or differences between DLB and PD.METHODS:
A SPECT scan was carried out 3 to 4 hours after administration of 185 MBq (IV) of FP-CIT. Using occipital cortex as a radioactivity uptake reference, ratios for the caudate nuclei and the anterior and posterior putamina of both hemispheres were calculated. From the FP-CIT binding measurements, asymmetry indices and caudateputamen ratios were derived.RESULTS:
The DLB and PD groups had lower FP-CIT binding in all striatal areas than controls (analysis of variance p < 0.001 in all measures). DLB patients also had significantly lower binding in the caudate nucleus than the PD patients. There was greater asymmetry of uptake in the posterior putamina of PD patients than DLB patients (p < 0.04) and controls (p < 0.01). The mean caudateputamen ratio for the DLB group was not significantly different from that of the controls, while the mean caudateputamen ratio of the PD group was higher than that of the control group (p < 0.001) and the DLB group (p < 0.001).CONCLUSION:
This study showed differences between PD and DLB in the pattern of striatal dopaminergic dysfunction. DLB patients do not have the characteristic selective degeneration of ventrolateral nigral neurons seen in PD. This could explain some of the clinical differences between DLB and PD.
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Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
/
Proteínas de Transporte de Membrana
/
Glicoproteínas de Membrana
/
Cuerpo Estriado
/
Enfermedad por Cuerpos de Lewy
/
Proteínas del Tejido Nervioso
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
Neurology
Año:
2004
Tipo del documento:
Article