Expression of growth differentiation factor-5 in the developing and adult rat brain.
Brain Res Dev Brain Res
; 151(1-2): 199-202, 2004 Jul 19.
Article
en En
| MEDLINE
| ID: mdl-15246706
Expression of the dopaminergic neurotrophin GDF-5 in developing rat ventral mesencephalon (VM) was found to begin at embryonic day (E) 12 and peak on E14, when dopaminergic neurones undergo terminal differentiation. In the adult rat, GDF-5 was found to be restricted to heart and brain, being expressed in many areas of the brain, including striatum and midbrain. This indicates a role for GDF-5 in the development and maintenance of dopaminergic neurones.
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Base de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Regulación del Desarrollo de la Expresión Génica
/
Proteínas Morfogenéticas Óseas
Idioma:
En
Revista:
Brain Res Dev Brain Res
Asunto de la revista:
CEREBRO
/
NEUROLOGIA
Año:
2004
Tipo del documento:
Article