Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials.
Bioorg Med Chem Lett
; 14(18): 4735-9, 2004 Sep 20.
Article
en En
| MEDLINE
| ID: mdl-15324898
ABSTRACT
A series of potential antimicrobial derivatives possessing bioisosteric replacements for the central oxazolidinone ring found in oxazolidinone antibacterials have been prepared. The design concept involved replacement of the requisite sp(3)-hybridized stereogenic center found at the 5-position of the oxazolidinone with a nitrogen atom. The synthesis and antibacterial activity of three such ring systems, the benzisoxazolinones, pyrroles, and isoxazolinones is described.
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Base de datos:
MEDLINE
Asunto principal:
Oxazolona
/
Oxazolidinonas
/
Isoxazoles
/
Antibacterianos
/
Nitrógeno
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2004
Tipo del documento:
Article