Tumor necrosis factor gene polymorphisms and inflammatory response in coronary artery bypass grafting patients.
Scand Cardiovasc J
; 38(5): 312-7, 2004 Oct.
Article
en En
| MEDLINE
| ID: mdl-15513316
ABSTRACT
BACKGROUND:
Tumor necrosis factor-alpha (TNF-alpha), a key factor in the inflammatory cascade, has been implicated in coronary artery disease. Two biallelic polymorphisms in the TNF gene locus (TNFA at position -308 and TNFB at +252) may influence TNF-alpha production. Individuals with the rare TNFA2 allele or TNFB2 homozygosity have augmented TNF-alpha production. We investigated the genotypes associated with increased TNF-alpha production in coronary artery bypass grafting (CABG) patients and if these genotypes influence the magnitude of the postoperative inflammatory response.METHODS:
TNF gene polymorphisms were analyzed by multiplex fluorescent solid-phase minisequencing in 86 CABG patients. Plasma concentrations of TNF-alpha, IL-6 and C3a and C-reactive protein (CRP) were analyzed before and after surgery in 45 of the patients and compared with genetically high and low TNF-alpha producers.RESULTS:
Thirty percent of the patients carried the TNFA2 allele and 45% were TNFB2 homozygous. The allelic frequencies were TNFA1/TNFA2 = 0.84/0.16 and TNFB1/TNFB2 = 0.32/0.68. Pre- and postoperative levels of TNF-alpha, IL-6, C3a and CRP did not differ significantly between genetically high and low TNF-alpha producers.CONCLUSIONS:
The frequency of high TNF-alpha producing genotypes in a CABG population was comparable to that previously reported from normal populations. Furthermore, we found no evidence that the investigated TNF-alpha gene polymorphisms influence postoperative inflammatory response after uncomplicated coronary surgery.
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Base de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
/
Enfermedad de la Arteria Coronaria
/
Puente de Arteria Coronaria
/
Factor de Necrosis Tumoral alfa
/
Inflamación
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Scand Cardiovasc J
Asunto de la revista:
ANGIOLOGIA
/
CARDIOLOGIA
Año:
2004
Tipo del documento:
Article