Restoration of axotomy-induced PACAP gene induction in SCID mice with CD4+ T-lymphocytes.
Neuroreport
; 15(17): 2647-50, 2004 Dec 03.
Article
en En
| MEDLINE
| ID: mdl-15570170
ABSTRACT
PACAP is a neuropeptide with putative neuroprotective, regenerative, and immunomodulatory actions. PACAP mRNA is up-regulated in motor neurons following facial nerve axotomy in wild type, but not immunodeficient SCID mice. Because CD4+ lymphocytes appear to be neuroprotective in facial nerve and other injury models, we studied PACAP gene expression in SCID mice preinfused with CD4+ enriched splenocytes. Whereas the mean number of PACAP hybridizing neurons after axotomy was reduced by 75% in uninfused SCID mice, infusion of CD4+ enriched splenocytes restored the number to a value not significantly different than controls. The CD4+ cell-dependent induction of PACAP in motor neurons may thus be a factor in the cascade of events triggered by immune cells that ultimately lead to nerve regeneration.
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Base de datos:
MEDLINE
Asunto principal:
Neuropéptidos
/
Linfocitos T CD4-Positivos
/
Regulación de la Expresión Génica
/
Neurotransmisores
/
Factores de Crecimiento Nervioso
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Neuroreport
Asunto de la revista:
NEUROLOGIA
Año:
2004
Tipo del documento:
Article