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Release of indomethacin from ultrasound dry granules containing lactose-based excipients.
Cavallari, Cristina; Albertini, Beatrice; Rodriguez, Lorenzo; Rabasco, Antonio M; Fini, Adamo.
Afiliación
  • Cavallari C; Dipartimento di Scienze Farmaceutiche, Università di Bologna, Italy.
J Control Release ; 102(1): 39-47, 2005 Jan 20.
Article en En | MEDLINE | ID: mdl-15653132
ABSTRACT
Physical mixtures were prepared containing indomethacin and beta-lactose and alpha-lactose-based excipients (Ludipress and Cellactose). The mixtures were compacted with the aid of ultrasound, obtaining tablets, which were milled and sieved. Granules thus obtained were examined by optical microscopy and differential scanning calorimetry. The intense yellow color of the granules and the absence of indomethacin peak in thermograms suggest important modifications of indomethacin physical state; the drug thus modified appears to be spread on the excipient particle surface as a thin film, giving a lustrous appearance. No influence of ultrasound was observed on phase transition concerning lactose; only loss of water was important under high energy ultrasound. Dissolution profiles suggest an increased release of the drug from the systems treated with ultrasound at high energy, with respect to a traditional compaction; while no difference could be evidenced among the three excipients that, however, appear all suitable for this ultrasound-aided direct compression process.
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Base de datos: MEDLINE Asunto principal: Ultrasonido / Indometacina / Industria Farmacéutica / Excipientes / Lactosa Idioma: En Revista: J Control Release Asunto de la revista: FARMACOLOGIA Año: 2005 Tipo del documento: Article
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Base de datos: MEDLINE Asunto principal: Ultrasonido / Indometacina / Industria Farmacéutica / Excipientes / Lactosa Idioma: En Revista: J Control Release Asunto de la revista: FARMACOLOGIA Año: 2005 Tipo del documento: Article