Synthesis and antimycobacterial activities of glycosylated amino alcohols and amines.
Eur J Med Chem
; 40(4): 351-60, 2005 Apr.
Article
en En
| MEDLINE
| ID: mdl-15804534
ABSTRACT
Reduction of glycosyl beta-amino esters (6-14 and 25-30) with lithium aluminum hydride resulted in glycosyl amino alcohols (15-23 and 31-36) in good yields. However, reductive amination of glycosyl aldehydes (1-3) with different amines in presence of sodium borohydride resulted in good to moderate yields of glycosyl amines (37-41). All the compounds were evaluated for antitubercular activity against Mycobacterium tuberculosis H37Ra and H37Rv. Compounds 18, 21, 35 and 36 exhibited antitubercular activities with MIC ranging from 6.25 to 3.12 microg ml(-1).
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Base de datos:
MEDLINE
Asunto principal:
Aminas
/
Amino Alcoholes
/
Antibacterianos
/
Mycobacterium
Idioma:
En
Revista:
Eur J Med Chem
Año:
2005
Tipo del documento:
Article