Casein kinase I in the mammalian circadian clock.
Methods Enzymol
; 393: 408-18, 2005.
Article
en En
| MEDLINE
| ID: mdl-15817302
ABSTRACT
The circadian clock is characterized by daily fluctuations in gene expression, protein abundance, and posttranslational modification of regulatory proteins. The Drosophila PERIOD (dPER) protein is phosphorylated by the serine?threonine protein kinase, DOUBLETIME (DBT). Similarly, the murine PERIOD proteins, mPER1 and mPER2, are phosphorylated by casein kinase I epsilon (CKI), the mammalian homolog of DBT. CKIepsilon also phosphorylates and partially activates the transcription factor BMAL1. Given the variety of potential targets for CKIepsilon and other cellular kinases, the precise role of phosphorylation is likely to be a complex one. Biochemical analysis of these and other circadian regulatory proteins has proven to be a fruitful approach in determining how they function within the context of the molecular clockworks.
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1
Base de datos:
MEDLINE
Asunto principal:
Factores de Transcripción
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Relojes Biológicos
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Proteínas Nucleares
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Proteínas de Ciclo Celular
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Caseína Cinasa 1 épsilon
Idioma:
En
Revista:
Methods Enzymol
Año:
2005
Tipo del documento:
Article