Geriatric autoimmune diseases: systemic lupus erythematosus, Sjogren's syndrome, and myositis.
Geriatrics
; 60(5): 32-8, 2005 May.
Article
en En
| MEDLINE
| ID: mdl-15877483
ABSTRACT
Systemic lupus erythematosus (SLE), Sjogren's syndrome (SS), and dermatomyositis (DM)/polymyositis (PM) may be encountered in geriatric patients due to improved survival rates in patients with younger ages of onset or from elderly-onset (EO) disease. EO disease accounts for up to 20% of patients affected by these disorders, and is typically insidious rather than acute. Whereas SS and DM/PM are considered autoimmune diseases with distinct organ specificity, SLE is a systemic disorder that may affect multiple organ systems. Commonly used clinical and laboratory criteria for defining and diagnosing these diseases were largely developed for patients age <65, and need to be modified in the geriatric patient. Therapeutic strategies include attention to ongoing drug regimens, medical comorbidities, and the roles of fatigue, depression, and arthropathy. Each disease may be responsive to low-dose corticosteroids, with a role for first or second-line immunosuppressives as steroid-sparing agents.
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Base de datos:
MEDLINE
Asunto principal:
Síndrome de Sjögren
/
Lupus Eritematoso Sistémico
/
Miositis
Tipo de estudio:
Diagnostic_studies
/
Guideline
/
Prevalence_studies
/
Risk_factors_studies
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Geriatrics
Año:
2005
Tipo del documento:
Article