Does the animal-to-human uncertainty factor incorporate interspecies differences in surface area?
Regul Toxicol Pharmacol
; 15(2 Pt 1): 172-9, 1992 Apr.
Article
en En
| MEDLINE
| ID: mdl-1626068
ABSTRACT
Risk assessment practices for noncarcinogens typically employ an uncertainty factor (UF) for animal-to-human extrapolation when defining acceptable levels for humans based on animal studies. EPA has interpreted the use of this factor as addressing interspecies differences due to dose normalization via surface area (exposure-dose relationships) and to innate differences in species susceptibility (dose-response relationships). Thus EPA has concluded that dose normalization via surface area is not necessary when using animal studies to define acceptable levels for noncarcinogens for humans. In this report we challenge this position on both theoretical and practical grounds. It is recommended that the UF for animal-to-human extrapolation for noncarcinogens in the risk assessment process and the technique for dose normalization be considered distinctly.
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Base de datos:
MEDLINE
Asunto principal:
Superficie Corporal
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Regul Toxicol Pharmacol
Año:
1992
Tipo del documento:
Article