Rapid accurate mass desorption electrospray ionisation tandem mass spectrometry of pharmaceutical samples.
Rapid Commun Mass Spectrom
; 19(24): 3643-50, 2005.
Article
en En
| MEDLINE
| ID: mdl-16287035
ABSTRACT
Desorption electrospray ionisation (DESI) has been successfully combined with a hybrid quadrupole time-of-flight mass spectrometer to provide mass spectra and product ion mass spectra of active ingredients formulated in pharmaceutical tablets, gels and ointments. Accurate mass data has been obtained from the DESI mass spectra and of the product ion fragments of selected ions, greatly enhancing the selectivity and information content of the experiment. This accurate mass information only takes seconds to acquire since the DESI technique does not require any sample preparation or extraction prior to mass analysis.
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Base de datos:
MEDLINE
Asunto principal:
Preparaciones Farmacéuticas
/
Espectrometría de Masa por Ionización de Electrospray
Idioma:
En
Revista:
Rapid Commun Mass Spectrom
Año:
2005
Tipo del documento:
Article