The incidence of T-cell receptor gene rearrangements in childhood B-lineage acute lymphoblastic leukemia is related to immunophenotype and fusion oncogene expression.
Leuk Res
; 30(7): 795-800, 2006 Jul.
Article
en En
| MEDLINE
| ID: mdl-16386788
ABSTRACT
Immunoglobulin (Ig) and T-cell receptor (TCR) gene rearrangement is conventionally used for assessment of lymphoid malignant cells. TCR genes rearrangements were reported to occur at high frequency in B-lineage acute lymphoblastic leukemia (ALL). Therefore, we have analyzed 83 children with acute B-lineage ALL (67 de novo patients and 19 relapses) by PCR analysis for clonal IgH, incomplete TCRD (Vdelta2-Ddelta3 and Ddelta2-Ddelta3) and TCRG rearrangements. It was shown that clonal cross-lineage TCR rearrangements were associated with more immature immunophenotype (CD34+, CD117+, CyIgM-) of leukemic cells from patients' bone marrow (BM) samples as compared to cell samples without cross-lineage TCR rearrangements. That was equally detected both in de novo and relapsed cases of disease. Low frequency of clonal TCRG rearrangements was associated with expression of E2A/PBX chimeric oncogene. We suggest that TCRG and TCRD clonal rearrangements in leukemic B-cells are associated with early stages of their differentiation.
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Base de datos:
MEDLINE
Asunto principal:
Receptores de Antígenos de Linfocitos T
/
Proteínas de Fusión Oncogénica
/
Proteínas de Fusión bcr-abl
/
Linfoma de Burkitt
/
Proteínas de Homeodominio
/
Proteína de la Leucemia Mieloide-Linfoide
/
Subunidad alfa 2 del Factor de Unión al Sitio Principal
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
Tipo de estudio:
Diagnostic_studies
/
Incidence_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Leuk Res
Año:
2006
Tipo del documento:
Article