Oral, more than transdermal, oestrogen therapy lowers asymmetric dimethylarginine in healthy postmenopausal women: a randomized, placebo-controlled study.
J Intern Med
; 259(2): 199-208, 2006 Feb.
Article
en En
| MEDLINE
| ID: mdl-16420549
ABSTRACT
OBJECTIVE:
To compare the effects of oral and transdermal hormone therapy (HT) on asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, in postmenopausal women.DESIGN:
In a multicentre, placebo-controlled, double-blind study, 152 hysterectomized healthy women were randomized to receive daily transdermal 17beta-oestradiol (tE2, n = 33), or oral micronized 17beta-oestradiol either unopposed (oE2, n = 37), or continuous combined with gestodene (oE2 + G, n = 33), or placebo (n = 49) for 13, 28-day treatment cycles. Plasma concentrations of ADMA, arginine and symmetric dimethylarginine (SDMA) were measured at baseline and in treatment cycles 4 and 13 with a high-performance liquid chromatography method.RESULTS:
After 13 cycles all active treatment groups showed a significant reduction in ADMA compared with placebo tE2, -4.0% (95% CI -7.5 to -0.6%); oE2, -7.7% (95% CI -10.9 to -4.4%) and oE2 + G, -7.5% (95% CI -10.8 to -4.3%). ancova showed a significantly larger reduction in the oral groups compared with the transdermal group (tE2 vs. oE2 and tE2 vs. oE2 + G, both P < 0.01). Oral, but not transdermal treatment, significantly reduced arginine compared with placebo. All active treatments reduced SDMA; however, this was only statistically significant in the oE2 group.CONCLUSION:
Reduction of ADMA was more pronounced after oral than after tE2 administration. Adding gestodene to oral 17beta-oestradiol did not alter the reduction of ADMA. The clinical implications of these findings remain uncertain; however, the decrease of ADMA by 17beta-oestradiol could be a key phenomenon in the modulation of nitric oxide synthesis by postmenopausal HT.
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Base de datos:
MEDLINE
Asunto principal:
Arginina
/
Terapia de Reemplazo de Estrógeno
/
Posmenopausia
/
Estrógenos
Tipo de estudio:
Clinical_trials
Idioma:
En
Revista:
J Intern Med
Asunto de la revista:
MEDICINA INTERNA
Año:
2006
Tipo del documento:
Article