Total synthesis of (-)-xyloketal A.
Org Lett
; 8(7): 1427-9, 2006 Mar 30.
Article
en En
| MEDLINE
| ID: mdl-16562908
ABSTRACT
[reaction see text] The first total synthesis of the C(3)-symmetric and biologically active natural product, (-)-xyloketal A, has been accomplished in one step from phloroglucinol (1,3,5-trihydroxybenzene) and (4R)-3-hydroxymethyl-2,4-dimethyl-4,5-dihydrofuran. This remarkably direct process involved an exceedingly facile and diastereoselective boron trifluoride diethyl etherate-promoted triple electrophilic aromatic substitution reaction that was coupled to three bicyclic acetal formation reactions.
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Base de datos:
MEDLINE
Asunto principal:
Piranos
/
Productos Biológicos
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2006
Tipo del documento:
Article