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In vitro susceptibilities of aerobic and facultatively anaerobic Gram-negative bacilli isolated from patients with intra-abdominal infections worldwide: 2004 results from SMART (Study for Monitoring Antimicrobial Resistance Trends).
Rossi, Flávia; Baquero, Fernando; Hsueh, Po-Ren; Paterson, David L; Bochicchio, Grant V; Snyder, Theresa A; Satishchandran, Vilas; McCarroll, Kathleen; DiNubile, Mark J; Chow, Joseph W.
Afiliación
  • Rossi F; Hospital das Clinicas da Faculdade de Medicina, São Paulo LIM 03, Brazil.
J Antimicrob Chemother ; 58(1): 205-10, 2006 Jul.
Article en En | MEDLINE | ID: mdl-16717055
OBJECTIVES: SMART (Study for Monitoring Antimicrobial Resistance Trends) is an ongoing study to monitor worldwide antimicrobial resistance trends among aerobic and facultatively anaerobic Gram-negative bacilli (GNB) isolated from intra-abdominal infections. This 2004 report summarizes the most recently completed annual data from SMART. METHODS: During 2004, 81 medical centres from 28 countries in five global regions collected intra-abdominal GNB for antimicrobial susceptibility testing using broth microdilution according to the Clinical and Laboratory Standards Institute guidelines. RESULTS: A total of 6156 unique aerobic and facultatively anaerobic GNB were isolated from intra-abdominal infections. Enterobacteriaceae composed 86% of the total isolates. Among the 12 antimicrobial agents tested, the carbapenems and amikacin were the most consistently active against the Enterobacteriaceae. Escherichia coli was the most commonly isolated species (48%), and the susceptibility rate to the quinolones was lowest in Asia/Pacific and Latin America. Extended-spectrum beta-lactamases (ESBLs) were detected phenotypically in 10% of E. coli, 17% of Klebsiella spp. and 22% of Enterobacter spp. worldwide, representing a slight increase over the two previous years. ESBL producers typically had a more antibiotic-resistant profile than non-ESBL producers but were usually susceptible to the carbapenems. CONCLUSIONS: Antimicrobial resistance among GNB isolated from intra-abdominal infections continued to be a problem worldwide in 2004, with the highest rates of resistance overall in the Asia/Pacific region. The carbapenems and amikacin were the most consistently active agents in vitro against Enterobacteriaceae isolated from intra-abdominal infections worldwide.
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Base de datos: MEDLINE Asunto principal: Infecciones por Bacterias Gramnegativas / Farmacorresistencia Bacteriana / Bacterias Gramnegativas / Antibacterianos Tipo de estudio: Guideline Idioma: En Revista: J Antimicrob Chemother Año: 2006 Tipo del documento: Article
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Base de datos: MEDLINE Asunto principal: Infecciones por Bacterias Gramnegativas / Farmacorresistencia Bacteriana / Bacterias Gramnegativas / Antibacterianos Tipo de estudio: Guideline Idioma: En Revista: J Antimicrob Chemother Año: 2006 Tipo del documento: Article