Sulfation patterns of glycosaminoglycans encode molecular recognition and activity.
Nat Chem Biol
; 2(9): 467-73, 2006 Sep.
Article
en En
| MEDLINE
| ID: mdl-16878128
ABSTRACT
Although glycosaminoglycans contribute to diverse physiological processes, an understanding of their molecular mechanisms has been hampered by the inability to access homogeneous glycosaminoglycan structures. Here, we assembled well-defined chondroitin sulfate oligosaccharides using a convergent, synthetic approach that permits installation of sulfate groups at precise positions along the carbohydrate backbone. Using these defined structures, we demonstrate that specific sulfation motifs function as molecular recognition elements for growth factors and modulate neuronal growth. These results provide both fundamental insights into the role of sulfation and direct evidence for a 'sulfation code' whereby glycosaminoglycans encode functional information in a sequence-specific manner analogous to that of DNA, RNA and proteins.
Buscar en Google
Base de datos:
MEDLINE
Asunto principal:
Sulfatos
/
Glicosaminoglicanos
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Nat Chem Biol
Asunto de la revista:
BIOLOGIA
/
QUIMICA
Año:
2006
Tipo del documento:
Article