Longterm visual prognosis in Usher syndrome types 1 and 2.
Acta Ophthalmol Scand
; 84(4): 537-44, 2006 Aug.
Article
en En
| MEDLINE
| ID: mdl-16879578
ABSTRACT
PURPOSE:
To estimate the age at diagnosis of retinitis pigmentosa and to determine visual acuity deterioration, visual field impairment and the frequency of cataracts in Usher syndrome types 1 and 2.METHODS:
We carried out a retrospective study of 328 affected subjects with Usher syndrome types 1 and 2. Study subjects were divided into seven different age groups by decade. Data were analysed using descriptive statistics, general linear model anova and survival analysis.RESULTS:
Retinitis pigmentosa was diagnosed significantly earlier in subjects with Usher syndrome type 1 than in those with type 2. Visual acuity was significantly more impaired in affected subjects with Usher syndrome type 1 than in those with type 2 from 50 years of age onwards. Survival analysis revealed a significant difference in visual field loss (CONCLUSIONS:
Progressive loss of visual acuity and visual field begins to be substantial between the second and third decades of life in both Usher types. The rate of degeneration varies between individuals in both groups. The data are useful for the counselling of affected subjects with Usher syndrome types 1 and 2.
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Base de datos:
MEDLINE
Asunto principal:
Trastornos de la Visión
/
Catarata
/
Agudeza Visual
/
Campos Visuales
/
Retinitis Pigmentosa
/
Síndromes de Usher
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Idioma:
En
Revista:
Acta Ophthalmol Scand
Asunto de la revista:
OFTALMOLOGIA
Año:
2006
Tipo del documento:
Article