Application of multicolor banding for identification of complex chromosome 18 rearrangements.
J Mol Diagn
; 8(4): 521-5; quiz 528, 2006 Sep.
Article
en En
| MEDLINE
| ID: mdl-16931594
ABSTRACT
Multicolor chromosome banding (mBAND) is a recently developed technique that allows the delineation of chromosomal regions with a resolution of a few megabase pairs. The resolution of mBAND is slightly below that of conventional chromosome banding; however, the color bands have a great value in identifying chromosomal abnormalities, particularly complex chromosome rearrangements, and intrachromosome exchanges (ie, inversions, deletions, duplications, and insertions). These abnormalities cannot be defined easily by conventional cytogenetic analysis or chromosome paint. In this report, we present the application of the mBAND analysis for identification of complex intrachromosome rearrangements of chromosome 18 in a child with dysmorphic features.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Cromosomas Humanos Par 18
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Reordenamiento Génico
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Aberraciones Cromosómicas
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Bandeo Cromosómico
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Pintura Cromosómica
Tipo de estudio:
Diagnostic_studies
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Evaluation_studies
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Prognostic_studies
Idioma:
En
Revista:
J Mol Diagn
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2006
Tipo del documento:
Article