The solution structure of the membrane-proximal cytokine receptor domain of the human interleukin-6 receptor.
Biol Chem
; 387(9): 1255-9, 2006 Sep.
Article
en En
| MEDLINE
| ID: mdl-16972794
ABSTRACT
The members of the interleukin-6-type family of cytokines interact with receptors that have a modular structure and are built of several immunoglobulin-like and fibronectin type III-like domains. These receptors have a characteristic cytokine receptor homology region consisting of two fibronectin type III-like domains defined by a set of four conserved cysteines and a tryptophan-serine-X-tryptophan-serine sequence motif. On target cells, interleukin-6 (IL-6) initially binds to its cognate alpha-receptor and subsequently to a homodimer of the signal transducer receptor gp130. The IL-6 receptor (IL-6R) consists of three extracellular domains. The N-terminal immunoglobulin-like domain is not involved in ligand binding, whereas the third membrane-proximal fibronectin-like domain (IL-6R-D3) accounts for more than 90% of the binding energy to IL-6. Here, we present the solution structure of the IL-6R-D3 domain solved by multidimensional heteronuclear NMR spectroscopy.
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Base de datos:
MEDLINE
Asunto principal:
Membrana Celular
/
Estructura Terciaria de Proteína
/
Receptores de Interleucina-6
Idioma:
En
Revista:
Biol Chem
Asunto de la revista:
BIOQUIMICA
Año:
2006
Tipo del documento:
Article