Odd-skipped genes specify the signaling center that triggers retinogenesis in Drosophila.
Development
; 133(21): 4145-9, 2006 Nov.
Article
en En
| MEDLINE
| ID: mdl-17021046
ABSTRACT
Although many of the factors responsible for conferring identity to the eye field in Drosophila have been identified, much less is known about how the expression of the retinal ;trigger', the signaling molecule Hedgehog, is controlled. Here, we show that the co-expression of the conserved odd-skipped family genes at the posterior margin of the eye field is required to activate hedgehog expression and thereby the onset of retinogenesis. The fly Wnt1 homologue wingless represses the odd-skipped genes drm and odd along the anterior margin and, in this manner, spatially restricts the extent of retinal differentiation within the eye field.
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Base de datos:
MEDLINE
Asunto principal:
Factores de Transcripción
/
Transducción de Señal
/
Genes de Insecto
/
Proteínas de Drosophila
/
Proteínas de Unión al ADN
/
Drosophila melanogaster
/
Morfogénesis
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Development
Asunto de la revista:
BIOLOGIA
/
EMBRIOLOGIA
Año:
2006
Tipo del documento:
Article