Increased spinal c-Fos expression with noxious and non-noxious peripheral stimulation after severe spinal contusion.
Neurosci Lett
; 413(1): 58-62, 2007 Feb 08.
Article
en En
| MEDLINE
| ID: mdl-17161529
ABSTRACT
The effects of severe contusive spinal cord injury (SCI), at thoracic level 8 (T8), on lumbar c-Fos expression in the spinal cord was investigated. As hypothesized, chronic SCI has a significant effect on expression of c-Fos in the dorsal spinal sensory areas with noxious and innocuous peripheral stimulation of the sciatic nerve. This alteration to stimulation effects was measured using counts of c-Fos immunoreactive cells in the dorsal horn of the L5 lumbar spinal cord in injured animals at 90 days post-injury and in uninjured controls. The number of c-Fos immunoreactive cells increased in SCI rats only after noxious peripheral stimulation (electrical and chemical) suggesting a general increase in excitability in spinal pathways (central sensitization) associated with chronic SCI. These altered responses may represent a functional anatomical reorganization of spinal cord circuitry leading to increased dorsal horn c-Fos expression as a response to severe chronic contusive damage to the spinal cord sensory pathways.
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Base de datos:
MEDLINE
Asunto principal:
Nervios Periféricos
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Traumatismos de la Médula Espinal
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Raíces Nerviosas Espinales
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Regulación de la Expresión Génica
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Proteínas Proto-Oncogénicas c-fos
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Neuronas Aferentes
Idioma:
En
Revista:
Neurosci Lett
Año:
2007
Tipo del documento:
Article