A highly effective one-pot synthesis of quinolines from o-nitroarylcarbaldehydes.

Li, An-Hu; Ahmed, Eilaf; Chen, Xin; Cox, Matthew; Crew, Andrew P; Dong, Han-Qing; Jin, Meizhong; Ma, Lifu; Panicker, Bijoy; Siu, Kam W; Steinig, Arno G; Stolz, Kathryn M; Tavares, Paula A R; Volk, Brian; Weng, Qinghua; Werner, Doug; Mulvihill, Mark J

Li, An-Hu; Ahmed, Eilaf; Chen, Xin; Cox, Matthew; Crew, Andrew P; Dong, Han-Qing; Jin, Meizhong; Ma, Lifu; Panicker, Bijoy; Siu, Kam W; Steinig, Arno G; Stolz, Kathryn M; Tavares, Paula A R; Volk, Brian; Weng, Qinghua; Werner, Doug; Mulvihill, Mark J.

Afiliación

Li AH; Department of Cancer Chemistry, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, NY 11735, USA. ali@osip.com

Org Biomol Chem ; 5(1): 61-4, 2007 Jan 07.

Article en En | MEDLINE | ID: mdl-17164907

RESUMEN

A highly effective one-pot Friedländer quinoline synthesis using inexpensive reagents has been developed. o-Nitroarylcarbaldehydes were reduced to o-aminoarylcarbaldehydes with iron in the presence of catalytic HCl (aq.) and subsequently condensed in situ with aldehydes or ketones to form mono- or di-substituted quinolines in high yields (66-100%).

Asunto(s)

Aldehídos/química; Benzaldehídos/química; Quinolinas/síntesis química; Hierro/química; Cetonas/química; Estructura Molecular; Oxidación-Reducción; Quinolinas/química

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Base de datos: MEDLINE Asunto principal: Quinolinas / Benzaldehídos / Aldehídos Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2007 Tipo del documento: Article

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