Insulin receptor activation in solitary fibrous tumours.
J Pathol
; 211(5): 550-554, 2007 Apr.
Article
en En
| MEDLINE
| ID: mdl-17299733
ABSTRACT
Solitary fibrous tumours (SFTs) are known to overexpress insulin-like growth factor 2 (IGF-2). The down-stream oncogenic pathways of IGF-2, however, are not clear. Here we report uniform activation of the insulin receptor (IR) pathway in SFTs, which are mesenchymal tumours frequently associated with hypoglycaemia. Whereas the IR and its downstream signalling pathways were constitutively activated in SFTs, insulin-like growth factor 1 receptor (IGF-1R) was not expressed in these tumours. We also find that SFT cells secrete IGF-2 and proliferate in serum-free medium, consistent with an IGF-2/IR autocrine loop. The aetiological relevance of IGF-2 is supported by expression of IR-A, the IR isoform with high affinity for IGF-2, in all SFTs. Our studies suggest that IR activation plays an oncogenic role in SFTs.
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1
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Pleurales
/
Receptor de Insulina
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Neoplasias de Tejido Fibroso
Idioma:
En
Revista:
J Pathol
Año:
2007
Tipo del documento:
Article