Analysis of HIV-1 CRF07_BC gag p6 sequences indicating novel deletions in the central region of p6.
Arch Virol
; 152(8): 1553-8, 2007.
Article
en En
| MEDLINE
| ID: mdl-17458619
ABSTRACT
We amplified gag sequences from 66 individuals infected with HIV-1 CRF07_BC during 2003-2005 in the Xinjiang region of China. A novel deletion of 7aa (including a KELY motif) in the central region of the CRF07_BC gag p6 domain was detected, which has not been reported in other HIV-1 subtypes. Further deletions of up to 13aa (including KQE and KELY motifs) was also found in this domain, representing the biggest natural deletion up to now. Moreover, the CD4+ count and viral load level indicated that 1-13aa deletions in CRF07_BC gag p6 do not have a significant effect on viral replication and fitness.
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Base de datos:
MEDLINE
Asunto principal:
Recombinación Genética
/
Productos del Gen gag
/
VIH-1
/
Eliminación de Secuencia
Idioma:
En
Revista:
Arch Virol
Año:
2007
Tipo del documento:
Article