Pharmacology and antitussive efficacy of 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a transient receptor potential vanilloid 1 antagonist in guinea pigs.

Bhattacharya, Anindya; Scott, Brian P; Nasser, Nadia; Ao, Hong; Maher, Michael P; Dubin, Adrienne E; Swanson, Devin M; Shankley, Nigel P; Wickenden, Alan D; Chaplan, Sandra R

Bhattacharya, Anindya; Scott, Brian P; Nasser, Nadia; Ao, Hong; Maher, Michael P; Dubin, Adrienne E; Swanson, Devin M; Shankley, Nigel P; Wickenden, Alan D; Chaplan, Sandra R.

Afiliación

Bhattacharya A; Department of Pain and Related Disorders, Johnson & Johnson Pharmaceutical Research and Development, LLC, 3210 Merryfield Row, San Diego, CA 92121, USA. abhatta2@prdus.jnj.com

J Pharmacol Exp Ther ; 323(2): 665-74, 2007 Nov.

Article en En | MEDLINE | ID: mdl-17690251

Asunto(s)

Aminopiridinas/farmacología; Antitusígenos/farmacología; Piperazinas/farmacología; Canales Catiónicos TRPV/antagonistas & inhibidores; Aminopiridinas/sangre; Animales; Células CHO; Tos/tratamiento farmacológico; Cricetinae; Cricetulus; Relación Dosis-Respuesta a Droga; Femenino; Cobayas; Masculino; Piperazinas/sangre

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Base de datos: MEDLINE Asunto principal: Antitusígenos / Piperazinas / Canales Catiónicos TRPV / Aminopiridinas Idioma: En Revista: J Pharmacol Exp Ther Año: 2007 Tipo del documento: Article

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