Apoptosis and proliferation differences between CD34+ and CD34- leukemic subpopulations in childhood acute leukemia.
Hematology
; 12(5): 403-7, 2007 Oct.
Article
en En
| MEDLINE
| ID: mdl-17852445
ABSTRACT
In view of the clinical and biological significance of leukemic heterogeneity we studied the efficacy of spontaneous apoptosis and cell cycle distribution in CD34+ and CD34 - leukemic subpopulations. Acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) leukemic samples with CD34 heterogeneous expression were separated into CD34+ and CD34 - fractions using fluorescence activated cell sorting. Cell cycle distribution, and apoptosis of the sorted subpopulations were estimated. CD34+ leukemic subpopulations had lower ability to apoptosis than that of CD34 - fractions in 6 out of 8 ALL samples and in 4 out of 5 AML samples. CD34+ fractions showed a higher percentage of proliferating cells compared to CD34 - cells in T-lineage ALL. These differences may lead to a more resistant phenotype of one of the subpopulations and reappearance this population in relapse.
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Base de datos:
MEDLINE
Asunto principal:
Leucemia Mieloide Aguda
/
Apoptosis
/
Antígenos CD34
/
Proliferación Celular
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
Idioma:
En
Revista:
Hematology
Asunto de la revista:
HEMATOLOGIA
Año:
2007
Tipo del documento:
Article