Sorl1 as an Alzheimer's disease predisposition gene?
Neurodegener Dis
; 5(2): 60-4, 2008.
Article
en En
| MEDLINE
| ID: mdl-17975299
ABSTRACT
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressively disabling impairments in memory, cognition, and non-cognitive behavioural symptoms. Sporadic AD is multifactorial and genetically complex. While several monogenic mutations cause early-onset AD and gene alleles have been suggested as AD susceptibility factors, the only extensively validated susceptibility gene for late-onset AD is the apolipoprotein E (APOE) epsilon4 allele. Alleles of the APOE gene do not account for all of the genetic load calculated to be responsible for AD predisposition. Recently, polymorphisms across the neuronal sortilin-related receptor (SORL1) gene were shown to be significantly associated with AD in several cohorts. Here we present the results of our large case-control whole-genome scan at over 500,000 polymorphisms which presents weak evidence for association and potentially narrows the association interval.
Buscar en Google
Base de datos:
MEDLINE
Asunto principal:
Proteínas de Transporte de Membrana
/
Predisposición Genética a la Enfermedad
/
Proteínas Relacionadas con Receptor de LDL
/
Enfermedad de Alzheimer
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Neurodegener Dis
Asunto de la revista:
NEUROLOGIA
Año:
2008
Tipo del documento:
Article