Decline of lactase activity and c/t-13910 variant in Sardinian childhood.
J Pediatr Gastroenterol Nutr
; 45(4): 503-6, 2007 Oct.
Article
en En
| MEDLINE
| ID: mdl-18030226
ABSTRACT
OBJECTIVES:
Our study aims to determine the age of onset of adult-type hypolactasia in Sardinians, and to establish the age at which genotyping of the C/T-13910 variant can be used reliably in the diagnosis of lactose malabsorption. PATIENTS ANDMETHODS:
A lactose breath hydrogen test was given to 383 randomly selected patients, from 3 to 19 years old.RESULTS:
The C/C-13910 genotype was found in 90% of patients; the frequency of the positive lactose breath hydrogen test increased with age and reached a prevalence of 85% at 9 years.CONCLUSIONS:
In Sardinians, adult-type hypolactasia becomes phenotypically evident in all individuals older than 9 years, suggesting that this should be considered the minimum age at which the genetic test for lactase nonpersistence should be applied.
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Base de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
/
Lactasa
/
Intolerancia a la Lactosa
Tipo de estudio:
Diagnostic_studies
/
Prevalence_studies
/
Risk_factors_studies
País/Región como asunto:
Europa
Idioma:
En
Revista:
J Pediatr Gastroenterol Nutr
Año:
2007
Tipo del documento:
Article