Galactosilated dopamine increases attention without reducing activity in C57BL/6 mice.
Behav Brain Res
; 187(2): 449-54, 2008 Mar 05.
Article
en En
| MEDLINE
| ID: mdl-18063140
ABSTRACT
Different strategies can be used to carry dopamine into the brain such as L-Dopa precursors or galactosilated form of DA (GAL-DA). The aim of this study was to investigate whether GAL-DA would reduce hyperactivity and increase non-selective attention (NSA) in a mouse model of attention deficit hyperactivity disorder (ADHD), as, i.e. C57BL/6 as did in NHE rats. Here we report that GAL-DA increases NSA in a spatial novelty in C57BL/6 mice. They received a single i.p. injection of GAL-DA (10 mg/kg or 100 mg/kg) or equimolar galactose vehicle. Another mouse strain the Swiss albino was introduced as inbred control group. Three hours after last injection mice were tested in a Làt-maze for 30-min. Behaviour was analyzed for horizontal (traveled distance) and vertical activity (orienting frequency and scanning durations) which shares cognitive and non-cognitive nature, respectively. Ten milligram per kilograms of GAL-DA, increases scanning duration in C57BL/6 mice. Thus a low dose of GAL-DA increases NSA without reducing hyperactivity in this mouse model of ADHD.
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Base de datos:
MEDLINE
Asunto principal:
Atención
/
Trastorno por Déficit de Atención con Hiperactividad
/
Dopamina
/
Aprendizaje por Laberinto
/
Galactosa
/
Actividad Motora
Idioma:
En
Revista:
Behav Brain Res
Año:
2008
Tipo del documento:
Article