Rapid assembly of diverse and potent allosteric Akt inhibitors.
Bioorg Med Chem Lett
; 18(6): 2211-4, 2008 Mar 15.
Article
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| MEDLINE
| ID: mdl-18296048
ABSTRACT
This paper describes the rapid assembly of four different classes of potent Akt inhibitors from a common intermediate. Among them, a pyridopyrimidine series displayed the best intrinsic and cell potency against Akt1 and Akt2. This series also showed a promising pharmacokinetic profile and excellent selectivity over other closely related kinases.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Ováricas
/
Neoplasias de la Próstata
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Piridinas
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Pirimidinas
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Inhibidores de Proteínas Quinasas
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Sitio Alostérico
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Proteínas Proto-Oncogénicas c-akt
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2008
Tipo del documento:
Article