AMP-activated protein kinase is essential for survival in chronic hypoxia.
Biochem Biophys Res Commun
; 370(2): 230-4, 2008 May 30.
Article
en En
| MEDLINE
| ID: mdl-18359290
ABSTRACT
This study was undertaken to interrogate cancer cell survival during long-term hypoxic stress. Two systems with relevance to carcinogenesis were employed Fully transformed BJ cells and a renal carcinoma cell line (786-0). The dynamic of AMPK activity was consistent with a prosurvival role during chronic hypoxia. This was further supported by the effects of AMPK agonists and antagonists (AICAR and compound C). Expression of a dominant-negative AMPK alpha resulted in a decreased ATP level and significantly compromised survival in hypoxia. Dose-dependent prosurvival effects of rapamycin were consistent with mTOR inhibition being a critical downstream mediator of AMPK in persistent low oxygen.
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Base de datos:
MEDLINE
Asunto principal:
Proteínas Quinasas
Idioma:
En
Revista:
Biochem Biophys Res Commun
Año:
2008
Tipo del documento:
Article